8th Baltic Congress of Radiology

08.10.2022  Tallinn, Estonia

Presentation

Small Hall

Synopsis: There is known relationship between hippocampal volumes and major depressive disorder (MDD), but the links between hippocampal volumes and suicidality remain unclear. If the hippocampus could be used as a biomarker of suicide attempts, it could be useful for prevention. In this study we compared hippocampal volumes between suicide attempters (SA) with MDD (n=21), SA without MDD (n=26) and healthy controls (HC) (n=59). Surface-based morphometry (Freesurfer) analysis was used to evaluate the volumes of gray matter. Although hippocampal volumes did not differ significantly between SA with and without MDD, both right (p=0.007) and left (p=0.006) hippocampi in SA with MDD and in SA without MDD (p=0.011; p=0.004) were reduced comparing them with HC. In SA with MDD analysis revealed the subregional deformations of the right subiculum (p=0.002) and CA1, CA3, CA4 subfields in the right (p=0.006; p=0.025; p=0.005) and left (p=0.015; p = 0.010; p=0.003) hippocampi. Similar volume changes of left CA4 (p=0.007) and CA1, CA3 in both right (p=0.007; p=0.019) and left (p=0.028; p=0.028) hippocampi were found in SA without MDD. Regardless of depressive disorder, atrophy is seen in both groups of suicide attempters and it is more noticeable than in the group of healthy controls. Both suicide groups showed similar hippocampal changes. Therefore, suicidality causes hippocampal changes on its own and can be distinguished from depressive disorder.

This agenda item is presented in the following session: S7-2 Neuroradiology

Plenary session

08.10.2022 13:30 - 15:00