8th Baltic Congress of Radiology

08.10.2022 Tallinn, Estonia

223Ra-treatment in mCRPC patients: based on the experience of 3 hospitals in Estonia

Alina Kornejeva (Estonia)

Radiologist, North Estonia Medical Centre

Biography: I was born in a relatively small town of Narva, Estonia, studied medicine in University of Tartu from 2009 to 2015. In 2015 I have started my career in North Estonia Medical Centre, at first as a radiology resident, then as a radiologist. Since 2018 my main field of interest is nuclear medicine, both diagnostics and isotope treatment. I find the concept of "theranostics" very elegant and believe that nuclear medicine can bring a more personalized approach to healthcare.

Presentation

Small Hall

Synopsis: Radium-223 dichloride (223Ra) is bone-targeted systemic treatment option for metastatic castration-resistant prostate cancer (mCRPC), that improves overall survival of patients. I would like to give a brief review based on our institution’s experience in numbers, also show some interesting cases and discuss the results. Up to 43% of patients (18/42) received all 6 injections, whereas 47% discontinued treatment due to different reasons. The most common reason is appearance of visceral metastasis, that was seen in 50% of patients who discontinued treatment (12/24). Up to 29% of patients (7/24) discontinued treatment due to hematological toxicity, at least one of them had histopathologically confirmed bone marrow malignant involvement. Up to 21% (5/24) of patients discontinued treatment due to rapid disease biochemical and clinical progression, one of them had also pathological vertebral fracture which resulted in paresis. Since 2013, when ALSYMPCA trial was published, new medications as well as radiopharmaceuticals have been introduced. Based on our clinical experience careful patient selection for treatment is crucial and so advanced Imaging techniques should be used whenever possible.

This agenda item is presented in the following session: S5-2 Prostata Imaging

Plenary session

08.10.2022 09:00 - 10:30