Baltic Atherosclerosis Conference 2021

03.12.2021 - 04.12.2021 Tallinn, Estonia

Genetics and atherosclerotic plaque composition. Is there a link?

Evija Knoka (Latvia)

Resident in Cardiology, Pauls Stradins Clinical University Hospital

Biography: Dr. Evija Knoka is a resident in Cardiology working at Pauls Stradins Clinical University Hospital and Department of Internal Medicine at Riga Stradins University, Riga, Latvia. She is also a PhD student in Riga Stradins University and her PhD topic is “The role of genetic markers in the pathogenesis of early atherosclerosis and their correlation with plaque characteristics”. Dr.Knoka ir a co-author of peer reviewed publications and a board member of Latvian Society of Atherosclerosis and Hypertension.

Small Hall

Media:

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Synopsis: Atherosclerosis and its complications are a global problem. There are several widely known and proven risk factors that promote atherogenesis in the majority of patients. However, in some, mostly young patients, the cause of early atherosclerotic lesion formation cannot always be found. It highlights the need for new risk markers for early atherosclerosis diagnosis to prevent serious cardiovascular complications in these relatively young patients. The interest in the negative impact of genetic risk markers on atherosclerotic lesion formation is growing. Atherosclerosis related studies have shown that several microRNAs can affect the pathogenesis of atherosclerosis by their impact on vascular endothelial function, myocyte and immunological cell migration and proliferation. In addition, polygenic risk scores (PRSs) based on risk variants from genome-wide association studies can help in the prediction of coronary artery disease risk. The role of microRNA expression, PRS and specific genetic mutation impact on coronary plaque characteristics will be evaluated and authors study findings will be discussed in this presentation.

This agenda item is presented in the following session: S2 - Early atherosclerosis, hypertension and personalised prevention

Plenary session

03.12.2021 11:45 - 13:15